Pengaruh Paparan Benzena pada Jumlah Eritrosit, Leukosit, Trombosit dan Kadar Hemoglobin: Literatur Review
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Published
Jul 18, 2024
Abstract
Sistem hematopoietik merupakan suatu sistem yang berfungsi memproduksi sel darah matang seperti eritrosit, leukosit, dan trombosit. Sistem ini sangat rentan terhadap kerusakan yang disebabkan oleh zat asing atau zat kimia salah satunya yang disebabkan oleh benzena. Benzena merupakan cairan tak berwarna dengan bau yang manis yang menjadi salah satu bahan dasar dalam petrokimia dan sebagai pelarut yang penting di dalam dunia industri. Benzena dapat masuk ke dalam tubuh manusia melalui sistem pernapasan, sistem pencernaan, dan kulit. Artikel ini bertujuan untuk mengulas risiko paparan benzena terhadap jumlah eritrosit, leukosit, trombosit, dan kadar hemoglobin. Informasi didapatkan dari buku, artikel, dan beberapa hasil penelitian yang diperoleh dari 10 tahun terakhir yaitu tahun 2014 sampai dengan tahun 2024. Penelusuran online menggunakan Google, Google Scholar, dan ScienceDirect. Berdasarkan hasil telaah dari beberapa artikel benzena dapat menjadi salah satu faktor risiko terjadinya hematotoksisitas. Benzena dapat mempengaruhi jumlah eritrosit, leukosit, trombosit, dan kadar hemoglobin dengan cara mempengaruhi sel-sel dari sistem hematopoietik dan sumsum tulang.
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How to Cite
Mahdalena, V., Irsan Saleh, M. and Purnamasari, S. (2024) “Pengaruh Paparan Benzena pada Jumlah Eritrosit, Leukosit, Trombosit dan Kadar Hemoglobin: Literatur Review”, Ranah Research : Journal of Multidisciplinary Research and Development, 6(5), pp. 1507-1514. doi: 10.38035/rrj.v6i5.991.
References
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Christiansi, W. Y., & Keman, S. (2022). Literature Review: Hubungan Pajanan Benzena, Usia, dan Masa Kerja dengan Kadar Trans, Trans – Muconic Acid (ttMA) Urin pada Pekerja Terpapar Benzena. Media Gizi Kesmas, 11(2), 633–642.
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Kunle, O. P., Lawrence, A. A., Oluwabusola, A. A., & AbdulFatai, A. (2019). Assessment of Post Exposure of Benzene on Some Hematology Parameters and DNA Lesions on Adult Wistar Rats. Asian Journal of Immunology, 2(1), 1–10.
Moarref, M. P., Safavi, M., Mostafavi, M.-A., & Karami-Mohajeri, S. (2020). Sub-acute Exposure to Benzene Accelerates the Aging Process of Red Blood Cells; an In vivo Study. Iranian Journal of Blood & Cancer, 12(4), 131–137.
Mohamed, H. (2018). Hematological Assessment of Benzene Exposure Among Employees in RasElmengar Depository of El-Brega Company, Benghazi. Journal of Environmental & Analytical Toxicology, 8(4).
Nikmah, W. I., Hanani D., Y., & Budiyono. (2016). Hubungan Antara Paparan Benzena Dengan Profil Darah Pada Pekerja di Industri Percetakan X Kota Semarang. JURNAL KESEHATAN MASYARAKAT, 4(5), 213–220.
Oktariana, D., Legiran, L., Liana, P., Rahadiyanto, K. Y., Prasasty, G. D., Lusiana, E., & Tamzil, N. S. (2022). Transplantasi Stem Cell untuk Keganasan Hematologi. EJournal Kedokteran Indonesia, 10(2), 186–193.
Putri, F. R. K., Tualeka, A. R., Jalaludin, J., & Ahsan, A. (2022). Hubungan Konsentrasi Benzena dengan Kadar Eritosit Pada Pekerja Produksi AUP Surabaya. Media Gizi Kesmas, 11(1), 225–230.
Ramaiah, L., Bounous, D. I., & Elmore, S. A. (2013). Hematopoietic System. In B. Bolon, W. M. Haschek, C. G. Rousseaux, R. Ochoa, & M. A. Wallig (Eds.), Haschek and Rousseaux’s Handbook of Toxicologic Pathology: Vol. III (Third Edition, pp. 1863–1933). Academic Press.
Rich, A. L., & Orimoloye, H. T. (2016). Elevated Atmospheric Levels of Benzene and Benzene-Related Compounds from Unconventional Shale Extraction and Processing: Human Health Concern for Residential Communities. Environmental Health Insights, 10, 75–82.
Setiawan, I., Margowati, W. E. S., Andari, D., & Churochman, M. (2022). Efek Hirupan Benzene (C6H6) pada Sel Darah Merah dan Sel Darah Putih Tikus Putih Jantan (Rattus norvegicus) Strain Wistar. Herb-Medicine Journal, 5(4), 1–4.
Sukar. (2014). GAMBARAN PAPARAN BENZENE DALAM RUMAH TERHADAP PROFIL DARAH KAWASAN INDUSTRI DAN PEMUKIMAN. Jurnal Ekologi Kesehatan, 13(3), 190–200.
Sun, R., Zhang, J., Yin, L., & Pu, Y. (2014). Investigation into Variation of Endogenous Metabolites in Bone Marrow Cells and Plasma in C3H/He Mice Exposed to Benzene. International Journal of Molecular Sciences, 15(3), 4994–5010.
Vermeulen, R., Lan, Q., Qu, Q., Linet, M. S., Zhang, L., Li, G., & Portengen, L. (2023). Nonlinear low dose hematotoxicity of benzene; a pooled analyses of two studies among Chinese exposed workers . Environment International , 177.
Alshareef, A. A., & Ibrahim, M. (2020). Probable Toxicity of Benzene Inhalation on Nervous System and Blood Image of Gas Station Workers. Journal of Biochemical Technology, 10(2), 71–76.
Bao, E. L., Cheng, A. N., & Sankaran, V. G. (2019). The Genetics of Human Hematopoiesis and Its Disruption in Disease. EMBO Molecular Medicine, 11(8).
Berthelet, J., Michail, C., Bui, L.-C., Coadou, L. Le, Sirri, V., Wang, L., Dulphy, N., & Dupret, J.-M. (2021). The Benzene Hematotoxic and Reactive Metabolite 1,4-Benzoquinone Impairs the Activity of the Histone Methyltransferase SET Domain Containing 2 (SETD2) and Causes Aberrant Histone H3 Lysine 36 Trimethylation (H3K36me3). MOLECULAR PHARMACOLOGY , 100(3), 283–294.
Bestari, M. A. D., Tualeka, A. R., Alayyannur, P. A., Arini, S. Y., Russeng, S. S., Rahmawati, P., & Susilowati, I. H. (2020). Relationship between Benzene Concentrations with Erythrocyte, Hemoglobin, and Health Complaints of Workers in Surabaya Printing Industry. Indian Journal of Forensic Medicine & Toxicology, 14(4), 3112–3119.
Brekalo-Lazarevic, S., Begic, A., Ademovic, Z., & Horozic, E. (2018). Determination of Benzene Metabolite Phenol in The Urine and Analysis of Blood Parameters of Workers Exposed to Benzene. International Journal of Current Advanced Research, 7(7), 14031–14035.
Carter, C. M. (2018). Alterations in Blood Components. In C. McQueen (Ed.), Comprehensive Toxicology (Third Edition, Vol. 12, pp. 249–293). Elsevier Science.
Chen, L., Guo, P., Zhang, H., Li, W., Gao, C., Huang, Z., Fan, J., Zhang, Y., Li, X., Liu, X., & Wang, F. (2019). Benzene-induced mouse hematotoxicity is regulated by a protein phosphatase 2A complex that stimulates transcription of cytochrome P4502E1. J. Biol. Chem, 294(7), 2486–2499.
Christiansi, W. Y., & Keman, S. (2022). Literature Review: Hubungan Pajanan Benzena, Usia, dan Masa Kerja dengan Kadar Trans, Trans – Muconic Acid (ttMA) Urin pada Pekerja Terpapar Benzena. Media Gizi Kesmas, 11(2), 633–642.
D’Andrea, M. A., & Reddy, G. K. (2018). Health Risks Associated With Benzene Exposure in Children: A Systematic Review. Global Pediatric Health, 5, 1–10.
Harrison R., Saborit JMD., Dor F., & Henderson R. (2010). Benzene. In WHO guidelines for indoor air quality: selected pollutants. (pp. 15–54). World Health Organization Regional Office for Europe.
Kunle, O. P., Lawrence, A. A., Oluwabusola, A. A., & AbdulFatai, A. (2019). Assessment of Post Exposure of Benzene on Some Hematology Parameters and DNA Lesions on Adult Wistar Rats. Asian Journal of Immunology, 2(1), 1–10.
Moarref, M. P., Safavi, M., Mostafavi, M.-A., & Karami-Mohajeri, S. (2020). Sub-acute Exposure to Benzene Accelerates the Aging Process of Red Blood Cells; an In vivo Study. Iranian Journal of Blood & Cancer, 12(4), 131–137.
Mohamed, H. (2018). Hematological Assessment of Benzene Exposure Among Employees in RasElmengar Depository of El-Brega Company, Benghazi. Journal of Environmental & Analytical Toxicology, 8(4).
Nikmah, W. I., Hanani D., Y., & Budiyono. (2016). Hubungan Antara Paparan Benzena Dengan Profil Darah Pada Pekerja di Industri Percetakan X Kota Semarang. JURNAL KESEHATAN MASYARAKAT, 4(5), 213–220.
Oktariana, D., Legiran, L., Liana, P., Rahadiyanto, K. Y., Prasasty, G. D., Lusiana, E., & Tamzil, N. S. (2022). Transplantasi Stem Cell untuk Keganasan Hematologi. EJournal Kedokteran Indonesia, 10(2), 186–193.
Putri, F. R. K., Tualeka, A. R., Jalaludin, J., & Ahsan, A. (2022). Hubungan Konsentrasi Benzena dengan Kadar Eritosit Pada Pekerja Produksi AUP Surabaya. Media Gizi Kesmas, 11(1), 225–230.
Ramaiah, L., Bounous, D. I., & Elmore, S. A. (2013). Hematopoietic System. In B. Bolon, W. M. Haschek, C. G. Rousseaux, R. Ochoa, & M. A. Wallig (Eds.), Haschek and Rousseaux’s Handbook of Toxicologic Pathology: Vol. III (Third Edition, pp. 1863–1933). Academic Press.
Rich, A. L., & Orimoloye, H. T. (2016). Elevated Atmospheric Levels of Benzene and Benzene-Related Compounds from Unconventional Shale Extraction and Processing: Human Health Concern for Residential Communities. Environmental Health Insights, 10, 75–82.
Setiawan, I., Margowati, W. E. S., Andari, D., & Churochman, M. (2022). Efek Hirupan Benzene (C6H6) pada Sel Darah Merah dan Sel Darah Putih Tikus Putih Jantan (Rattus norvegicus) Strain Wistar. Herb-Medicine Journal, 5(4), 1–4.
Sukar. (2014). GAMBARAN PAPARAN BENZENE DALAM RUMAH TERHADAP PROFIL DARAH KAWASAN INDUSTRI DAN PEMUKIMAN. Jurnal Ekologi Kesehatan, 13(3), 190–200.
Sun, R., Zhang, J., Yin, L., & Pu, Y. (2014). Investigation into Variation of Endogenous Metabolites in Bone Marrow Cells and Plasma in C3H/He Mice Exposed to Benzene. International Journal of Molecular Sciences, 15(3), 4994–5010.
Vermeulen, R., Lan, Q., Qu, Q., Linet, M. S., Zhang, L., Li, G., & Portengen, L. (2023). Nonlinear low dose hematotoxicity of benzene; a pooled analyses of two studies among Chinese exposed workers . Environment International , 177.